Development of pH-Responsive Interpenetrating Polymer Networks of Polyacrylamide-g-Gum Arabica and Sodium Alginate for Gastroprotective Delivery of Gabapentin

In the present work, a grafted polymer of polyacrylamide with gum arabica was synthesized as Gum acacia-g-polyacrylamide using microwave-assisted synthesis ceric ammonium nitrate reaction initiator. The utilized in combination sodium alginate to prepare interpenetrating network hydrogel beads effectively deliver gabapentin gastrointestinal tract. formulated microbeads showed pH-responsive release different medium. were processed for analytical characterization like Fourier transform infrared spectroscopy, differential scanning calorimetry, X-ray powder diffraction and electron microscopy. spectroscopy study confirms formation whereas studies confirm appearance microbead formulations. drug from structured found higher pH 6.8 compared 1.2 7.4 indicating effective delivery upper duodenum better absorption.